In short
Perindopril is a chemically synthesised medicine that belongs to the group of drugs called ACE inhibitors. It is already authorised as a medicine and appears in one registered clinical trial as a comparator drug in heart failure. The trial, a Phase 3 study with 368 participants, investigates whether up-titration of guideline-directed medical therapy including perindopril can improve outcomes in women with heart failure compared with usual care.
Key points
- Perindopril is an ACE inhibitor authorised as a medicine and used as a comparator in a heart failure trial.
- The trial is a Phase 3 randomised study with 368 participants.
- It compares up-titration of heart failure medicines, including perindopril, against usual care.
- The primary endpoint is all-cause mortality, heart failure readmission or worsening heart failure within one year.
- The trial is currently authorised and is being conducted in heart failure.
What is on this page?
- What is perindopril?
- How does perindopril work?
- Which conditions is perindopril used or studied for?
- How is perindopril given?
- What do the clinical trials show?
- What side effects are known?
What is perindopril?
Perindopril is a chemically synthesised medicine that belongs to the class of drugs called ACE inhibitors. It is already authorised as a medicine. In the clinical trial registry, perindopril is listed as a comparator drug, meaning it is used as a reference treatment against which other approaches are compared. The form of perindopril described in the registry is perindopril arginine, which is available as oral tablets. Perindopril is also known by its international non-proprietary name, perindopril arginine.
How does perindopril work?
Perindopril belongs to the group of medicines called ACE inhibitors. ACE stands for angiotensin-converting enzyme. This enzyme plays a role in producing a substance that narrows blood vessels and raises blood pressure. By blocking this enzyme, perindopril helps blood vessels relax and widen, which can reduce the workload on the heart. In the heart failure trial, perindopril is used as part of a broader set of heart failure medicines known as guideline-directed medical therapy.
Which conditions is perindopril used or studied for?
- Heart failure — a condition in which the heart cannot pump blood well enough to meet the body's needs. Perindopril appears as a comparator in a clinical trial for heart failure.
How is perindopril given?
Perindopril arginine is available as oral tablets. In the clinical trial, perindopril is listed at doses of 4 mg and 8 mg. The route of administration recorded in the registry is buccal use, although the product information describes the tablet as an oral form.
What do the clinical trials show?
One registered clinical trial includes perindopril as a comparator drug. The trial is a Phase 3 randomised study with 368 participants. It is authorised and is being conducted in heart failure. The study compares up-titration of guideline-directed medical therapy, including perindopril, against usual care in women with heart failure. The primary outcome is all-cause mortality within one year, heart failure readmission, or worsening heart failure. The trial also looks at quality of life, adherence to medication, and side effects.
What side effects are known?
The sources provided do not give a list of side effects for perindopril. The clinical trial record mentions that side effects are among the outcomes assessed, but no specific side effects are described.