Azienda Ospedaliero Universitaria Careggi

At Azienda Ospedaliero Universitaria Careggi, a major share of research in oncology focuses on a wide range of solid tumors, especially breast cancer, non-small cell lung cancer, colorectal cancer, gastric cancer, and renal cell carcinoma. Many studies aim to test new treatment strategies, improve outcomes after standard therapy, and better control advanced or metastatic disease.

• Research in advanced and metastatic cancers, including lung, breast, colorectal, gastric, and kidney tumors
• Studies in head and neck cancer, ovarian cancer, pancreatic cancer, and urothelial carcinoma
• Trials evaluating new immunotherapy, targeted therapy, and combination treatment approaches

This activity reflects a strong focus on improving cancer control, extending survival, and refining treatment choices for patients with difficult-to-treat malignancies.

The site also has extensive research in hematology, with trials covering acute myeloid leukemia, chronic lymphocytic leukemia, multiple myeloma, myelodysplastic syndromes, myelofibrosis, and other blood and lymphatic diseases. These studies are designed to test new therapies, improve disease control, and support patients whose cancers have returned or no longer respond well to standard care.

• Studies in acute and chronic leukemias, including relapsed or high-risk disease
• Research in lymphoma and plasma cell disorders
• Trials focused on better symptom relief, deeper remission, and improved long-term outcomes

The breadth of this work shows a strong commitment to advancing care for both malignant and non-malignant blood disorders.

A substantial portion of research at Careggi addresses immune system diseases and chronic inflammatory conditions, including rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Crohn’s disease, ulcerative colitis, and asthma. The trials in this field often aim to reduce disease activity, improve daily symptoms, and evaluate whether newer immune-targeted treatments can offer better control than current care.

• Research in autoimmune rheumatic diseases and connective tissue disorders
• Studies in inflammatory bowel disease, including Crohn’s disease and ulcerative colitis
• Trials for asthma, vasculitis, and other immune-mediated conditions

This therapeutic area highlights the site’s strong interest in treatments that modulate the immune system more precisely and safely.

Clinical trials at Azienda Ospedaliero Universitaria Careggi also span cardiovascular disease and kidney disease, with research in atrial fibrillation, atherosclerotic cardiovascular disease, myocardial infarction, hypertrophic cardiomyopathy, chronic kidney disease, and IgA nephropathy. These studies generally seek to improve prevention, reduce complications, and test new approaches for patients at elevated risk of heart, vessel, or renal damage.

• Trials on stroke prevention, clotting risk, and rhythm-related heart disease
• Studies in cardiomyopathy, acute coronary syndromes, and surgical kidney protection
• Research in chronic kidney disease, nephropathy, and transplant-related kidney problems

The work combines treatment evaluation with efforts to better protect organ function and reduce long-term cardiovascular and renal events.

The site conducts notable research in neurology, eye diseases, and rare disorders, including multiple sclerosis, migraine, Alzheimer’s disease, diabetic macular edema, age-related macular degeneration, and Fabry disease. Many of these trials aim to improve symptom control, slow disease progression, or evaluate new options for conditions with limited treatment choices.

• Studies in demyelinating disease, headache disorders, and neurodegenerative conditions
• Research in retinal disease, macular degeneration, and diabetic eye complications
• Trials for inherited and uncommon disorders, including lysosomal and genetic diseases

This mix of common and rare conditions shows a broad interest in both everyday neurological care and highly specialized medicine.

Beyond cancer and immune-mediated disease, the research portfolio includes digestive system diseases, metabolic disorders, and other specialized fields such as diabetes, liver disease, psoriatic disease, and sleep and behavioral conditions. These studies often focus on improving disease control, evaluating better supportive care, or clarifying how treatment affects day-to-day health.

• Trials in liver, bowel, and metabolic conditions, including fatty liver disease and diabetes
• Research in dermatologic and musculoskeletal inflammatory disorders
• Selected studies in pain, neurological symptoms, and behavioral health-related conditions

Overall, the site supports a wide-ranging clinical research program that extends well beyond one specialty and addresses many unmet medical needs.