Stichting OLVG

Clinical research here is strongly centered on cardiovascular diseases, with studies in myocardial infarction, heart failure, atherosclerotic cardiovascular disease, stroke, and aortic valve stenosis. Many trials aim to improve prevention and treatment effectiveness, while others test new approaches to lower inflammation, reduce clotting risk, and protect the heart in high-risk patients.

• Testing new therapies to reduce major cardiovascular events and improve long-term heart outcomes
• Studying better strategies for heart failure, acute myocardial infarction, and valve disease
• Evaluating antithrombotic and lipid-lowering approaches for patients with elevated vascular risk

The site also contributes to research on treatment choices after procedures such as transcatheter aortic valve implantation and cardiac surgery, reflecting a broad focus on safer, more personalized care.

Stichting OLVG is active in cancer research across both solid tumors and blood cancers, including breast cancer, colorectal cancer, pancreatic cancer, non-small cell lung cancer, lymphoma, and acute myeloid leukemia. These studies are mainly designed to test new treatment combinations, improve survival, and refine care for patients who may not be candidates for intensive therapy.

• Evaluating novel immunotherapy and targeted treatment combinations in breast cancer and colorectal cancer
• Studying improved regimens for acute myeloid leukemia, CLL, and lymphoma
• Assessing whether treatment strategies can extend survival while reducing toxicity

Research in this area also includes biomarker-driven and personalized approaches, helping match patients with therapies that may be more effective for their disease profile.

Another major focus is the overlap between chronic kidney disease, type 2 diabetes, obesity, and cardiovascular risk. Trials at the site examine whether newer medicines can slow kidney decline, reduce heart-related complications, and improve metabolic health in people with complex long-term conditions.

• Testing treatments for chronic kidney disease in people with and without diabetes
• Evaluating therapies aimed at reducing kidney failure and heart failure events
• Studying weight-related and metabolic treatments for patients with obesity or elevated cardiovascular risk

These studies are intended to support earlier intervention and better protection of both kidney and heart function.

The site has a strong portfolio in digestive system diseases, especially rectal cancer, colon cancer, colorectal liver metastases, and surgical recovery after complex abdominal procedures. The research often focuses on improving cancer control, preserving organ function, and optimizing outcomes after surgery.

• Testing new treatment sequences for rectal cancer and early-stage colorectal disease
• Evaluating strategies to improve outcomes in resectable colorectal liver metastases
• Studying ways to reduce complications after abdominal and pancreatic surgery

Several studies also look at infection prevention and recovery after surgery, supporting safer care for patients undergoing major gastrointestinal operations.

Clinical trials at this hospital also address bacterial infections, sepsis, pneumonia, and Staphylococcus aureus bacteremia, with a practical focus on improving treatment decisions in acute care settings. The goal is often to reduce complications, shorten unnecessary antibiotic use, and improve survival in seriously ill patients.

• Studying better antibiotic strategies for sepsis and bloodstream infections
• Evaluating ways to reduce infectious complications after surgery
• Testing supportive care approaches in critically ill patients, including those receiving ECMO

These trials reflect the site’s interest in safer hospital care and more effective infection management across emergency and intensive care environments.

Research in this area includes hormonal disorders, secondary hyperparathyroidism, hyperthyroidism, polycystic ovary syndrome, and menopausal symptoms. Studies are designed to improve symptom control, support metabolic balance, and evaluate practical treatment options for everyday care.

• Testing treatments for thyroid disease and secondary hyperparathyroidism
• Exploring care options for perimenopausal women with sleep and mood concerns
• Assessing therapies that may improve quality of life in hormonal and reproductive conditions

This broad field shows how the site contributes to both chronic disease management and patient-centered symptom relief.

The research portfolio also includes neurological disorders, eye diseases, and mental disorders. Trials in these areas examine prevention after stroke or transient ischemic attack, treatment for myopia, and support for insomnia and related psychological symptoms.

• Studying ways to prevent recurrent events after stroke and TIA
• Evaluating treatment approaches for progressive myopia in children
• Assessing interventions for sleep problems and mood symptoms in midlife women

These projects highlight a mix of preventive care, symptom management, and quality-of-life research across several non-cardiac specialties.

At Stichting OLVG, several trials focus on improving outcomes around surgery, including blood clot prevention, bleeding reduction, and recovery after major procedures. This work spans orthopedic, cardiac, gastrointestinal, and vascular surgery, with the aim of making treatment safer and more tailored to patient risk.

• Evaluating personalized approaches to prevent venous thromboembolism after surgery
• Studying methods to reduce bleeding and postoperative complications
• Assessing recovery-focused interventions after cardiac and abdominal operations

The research supports better decision-making for surgeons and clinicians caring for patients at risk of both clotting and bleeding complications.