UMCG

At UMCG in Groningen, clinical research in Neurology focuses strongly on Parkinson’s disease and Alzheimer’s disease, with studies also touching on intracerebral haemorrhage and other brain disorders. The trials are exploring new treatment options, assessing safety and tolerability, and looking at whether therapies can better support brain function and patient outcomes.

• Studies in Parkinson’s disease are evaluating potential therapies aimed at symptom control and disease-related brain changes.
• Research in Alzheimer’s disease is examining safety and early signs of treatment benefit in people with cognitive decline.
• Work on intracerebral haemorrhage is testing ways to improve recovery and reduce later vascular complications.

The site’s neurology portfolio reflects a mix of treatment development and clinical evaluation, with a clear emphasis on disorders that affect movement, memory, and brain injury.

Clinical trials at UMCG include research in Cardiovascular Diseases that targets STEMI and stroke-related complications after brain bleeding. Several studies are also using advanced imaging and diagnostic approaches to better understand inflammation and treatment response, supporting more precise care in cardiovascular and cerebrovascular disease.

• Trials in STEMI are exploring new ways to reduce heart muscle injury and improve recovery after acute events.
• Research following intracerebral haemorrhage is focused on preventing later vascular events and improving long-term outcomes.
• Investigative Techniques are being used to measure inflammation and identify markers that may guide treatment decisions.

This area combines therapeutic testing with diagnostic innovation, aiming to make cardiovascular and cerebrovascular care more effective and better targeted.

The research landscape at UMCG also includes trials in Immune System Diseases and Musculoskeletal Diseases, especially giant cell arteritis and rheumatoid arthritis. These studies are examining inflammation in blood vessels and joints, with the goal of improving diagnosis, understanding disease activity, and supporting more effective treatment choices.

• Giant cell arteritis studies are using imaging to detect inflamed arteries and track disease activity.
• Rheumatoid arthritis research is looking at joint inflammation and how it can be measured more accurately.
• Some projects are also investigating immune-related side effects linked to cancer immunotherapy.

These trials highlight a strong interest in inflammatory disease, where better detection and clearer understanding of immune responses may lead to improved patient care.

In the area of Neoplasms, the site is involved in studies related to glioblastoma, non-small cell lung cancer, and broader cancer care. The research includes efforts to refine surgery, understand treatment-related immune effects, and evaluate new approaches that may improve safety and effectiveness for people with cancer.

• Glioblastoma research is focused on improving tumor visualization during surgery.
• Non-small cell lung cancer and other cancer studies are examining immune-related complications from treatment.
• Some trials are designed to better define how cancer therapies affect the nervous and rheumatologic systems.

This cancer portfolio combines therapeutic innovation with translational research, aiming to make treatment more precise and easier to monitor.

Additional trials at UMCG cover Digestive System Diseases and Male Urogenital Diseases, including advanced liver fibrosis and cirrhosis and erectile dysfunction. These studies are evaluating new therapies and helping clarify whether treatments can improve organ function and quality of life.

• Research in advanced liver fibrosis and cirrhosis is aimed at understanding disease progression and treatment response.
• Trials in erectile dysfunction are testing a potential therapy for safety and effectiveness.
• Some studies also include healthy volunteers to support early assessment of how new medicines behave in the body.

These projects broaden the site’s clinical trial activity beyond neurology, showing interest in both chronic organ disease and patient-centered symptom management.