Unidade Local De Saude De Lisboa Ocidental E.P.E.

At Unidade Local De Saude De Lisboa Ocidental E.P.E., clinical trials in cardiovascular diseases focus on major conditions such as atrial fibrillation, heart failure, hypertension, and broader atherosclerotic cardiovascular disease. The studies are designed to test new treatment options and measure whether they can reduce serious heart- and stroke-related events.

• Prevention of stroke, heart attack, and other major cardiovascular events
• Management of established vascular disease and high cardiovascular risk
• Evaluation of therapies for heart failure, cardiomyopathy, and lipid-related risk

This work reflects a strong interest in improving long-term outcomes for people with complex cardiovascular conditions.

The Serviço de Nefrologia is actively involved in studies across nutritional and metabolic diseases and reproductive and urinary physiological phenomena, with a strong emphasis on chronic kidney disease, IgA nephropathy, focal segmental glomerulosclerosis, and autosomal dominant polycystic kidney disease. These trials aim to slow kidney decline, reduce proteinuria, and improve kidney-related outcomes.

• Testing new approaches for proteinuria and kidney function preservation
• Studying progressive kidney diseases and inherited renal disorders
• Assessing therapies intended to delay worsening kidney disease

The site’s nephrology research also includes patients with advanced kidney disease and transplant-related complications, showing broad clinical engagement in renal care.

Several trials at this hospital/clinic explore immune system diseases such as lupus nephritis and other inflammatory kidney disorders. The research is centered on evaluating whether targeted therapies can better control immune-driven damage and improve renal response.

• Immune-related kidney inflammation and autoimmune renal disease
• Measures of proteinuria and renal response in active disease
• Safety and effectiveness of newer immune-targeted treatments

These studies are important for patients whose kidney disease is linked to abnormal immune activity and persistent inflammation.

Research at Unidade Local De Saude De Lisboa Ocidental E.P.E. also addresses outcomes after kidney transplantation, including delayed graft function and other high-risk post-transplant challenges. The goal is to improve recovery after transplant and support better function of the donated kidney.

• Reducing complications after deceased-donor kidney transplantation
• Improving early graft recovery and dialysis-free outcomes
• Evaluating therapies for transplant-related kidney injury

This area complements the site’s broader nephrology program by focusing on recovery, safety, and better long-term transplant success.

Another important part of the trial portfolio involves nutritional and metabolic diseases linked to kidney and heart health, including studies in obesity, elevated lipoprotein(a), and other cardiometabolic risk factors. These trials are designed to see whether new therapies can lower risk and protect both the heart and kidneys.

• Cardiometabolic risk reduction in people with kidney disease or vascular disease
• Evaluation of treatments for inflammation, lipids, and blood pressure control
• Prevention of future cardiovascular and renal complications

The research combines prevention and treatment goals, linking metabolic health with cardiovascular and renal protection.

The site also contributes to selected studies in children and other specialized populations, including pediatric pulmonary arterial hypertension and pediatric left ventricular systolic dysfunction. These trials focus on whether treatments are safe and effective in younger patients with serious heart or kidney-related conditions.

• Children with pulmonary vascular disease
• Pediatric heart failure and ventricular dysfunction
• Long-term safety and symptom improvement in specialized groups

By participating in these studies, the center supports research that extends beyond adult nephrology into carefully selected pediatric and cardiopulmonary conditions.