University Childrens Hospital Queen Fabiola

At University Childrens Hospital Queen Fabiola, clinical research in gastro-enterology focuses on inflammatory bowel disease in children and adolescents, especially Crohn's disease and ulcerative colitis. These studies are designed to assess new treatment options and better understand how well therapies control symptoms and support long-term disease remission.

• Research on pediatric moderately to severely active Crohn's disease
• Studies in pediatric and adolescent ulcerative colitis
• Evaluation of therapies aimed at improving clinical remission and digestive health outcomes

This work reflects a strong interest in improving care for young patients with chronic digestive system diseases, with attention to both symptom control and treatment effectiveness.

The site also supports research in rare congenital and hereditary diseases, including hypophosphatasia in pediatric participants. These trials aim to test whether new therapies can improve disease-related outcomes and provide better options for children living with uncommon metabolic conditions.

• Studies in pediatric hypophosphatasia
• Assessment of treatment benefits in children who have not previously received standard enzyme therapy
• Research focused on improving radiographic outcomes and overall disease management

This area highlights the hospital’s role in advancing care for rare pediatric disorders where effective treatment choices are especially important.

Clinical trials at this Brussels site include research on medulloblastoma, a pediatric brain tumor, with a focus on comparing treatment strategies and understanding their impact on long-term outcomes. The goal is to improve both disease control and the child’s future quality of life, including neurocognitive development.

• Studies in newly diagnosed, non-metastatic medulloblastoma
• Evaluation of treatment approaches for SHH-activated tumor subtypes
• Research measuring neurocognitive outcomes after therapy

This research area shows a commitment to pediatric oncology that looks beyond tumor response and considers the child’s development and daily functioning.

Although the main trial activity is concentrated in digestive and rare disease research, the site’s therapeutic profile also includes skin and connective tissue diseases, reflecting a broader clinical research interest in pediatric conditions that may affect growth, structure, and overall health.

• Coverage of skin and connective tissue diseases within the site’s therapeutic portfolio
• Participation in research across multiple pediatric disease areas
• Support for studies that may improve diagnosis and treatment planning in children

Together with the hospital’s other studies, this area adds to a diverse research environment led by experienced investigators in pediatric clinical trials.