University Hospital Maastricht

At University Hospital Maastricht, clinical trials in neoplasms and respiratory tract diseases focus on cancers such as small-cell lung cancer, non-small cell lung cancer, head and neck cancer, and lymphoma. These studies are designed to test new treatment options, compare them with current standards, and improve outcomes for people with advanced or difficult-to-treat disease.

• Evaluating new immunotherapy and targeted treatment approaches for lung cancer
• Comparing treatment strategies in head and neck cancer and lymphoma
• Studying better ways to extend survival and control disease progression

The research also includes personalized approaches for specific tumor features, reflecting a strong interest in matching treatment to the biology of each cancer.

The site’s Gynaecology department is involved in trials for cervical cancer and endometrial cancer, with a clear focus on refining treatment while preserving quality of life. These studies explore whether newer therapies can improve cancer control and, in selected patients, support fertility-sparing care.

• Testing treatment options for cervical cancer and mismatch-repair deficient endometrial cancer
• Assessing whether treatment can be effective while reducing long-term impact on fertility
• Improving outcomes after surgery in gynecologic oncology

This area of research combines cancer treatment with a patient-centered approach, especially for women who may benefit from less invasive life planning after therapy.

Trials in digestive system diseases at University Hospital Maastricht include studies in colon cancer, chronic pancreatitis, and neuroendocrine tumours. The goal is to improve treatment effectiveness, relieve symptoms, and identify better ways to track disease behavior.

• Evaluating new treatment approaches for resectable colon cancer
• Studying pain relief in chronic pancreatitis
• Assessing treatment continuation strategies in neuroendocrine tumours

This research reflects both cancer-focused care and efforts to improve symptom management in long-term digestive conditions.

The cardiovascular diseases portfolio includes research on subclinical heart failure and proximal deep vein thrombosis. These trials aim to improve early cardiac remodeling, support better heart function, and evaluate whether new clot-busting treatment options can be both effective and safe.

• Testing strategies to reverse early changes in heart failure
• Assessing new treatment options for deep vein thrombosis
• Measuring safety and clinical benefit in vascular disease care

The research combines prevention-oriented cardiology with treatment development for patients at risk of serious vascular complications.

Clinical trials in immune system diseases and virus diseases address impaired immunity, kidney transplantation, and COVID-19. These studies are focused on improving immune responses, strengthening vaccine effectiveness, and supporting safer care for transplant recipients and other vulnerable groups.

• Studying how to improve COVID-19 vaccination responses in kidney transplant patients
• Exploring immune function in people with impaired immunity
• Supporting safer treatment choices for patients with complex immune needs

This area highlights practical research aimed at reducing infection-related risk while protecting long-term health.

The site also conducts studies in otorhinolaryngologic diseases, skin and connective tissue diseases, and analytical, diagnostic and therapeutic techniques. Research includes Menière's disease, actinic keratosis, and diagnostic work for carcinoma of unknown primary.

• Testing symptom relief strategies for Menière's disease
• Evaluating treatment for actinic keratosis on the face or scalp
• Improving diagnostic methods to identify the origin of unknown primary cancer

These trials combine everyday clinical care with efforts to improve diagnosis and local disease control across several specialty areas.