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Denali Therapeutics Inc.
Sponsor

Denali Therapeutics Inc.

United States 161 Oyster Point Boulevard, 94080-2042, United States

About the sponsor

Research activity includes early Alzheimer’s disease and other disorders affecting cognitive decline and brain function, with interest in central nervous system biomarkers and neuroprotective approaches.

  • Early Alzheimer’s disease
  • Central nervous system activity
  • Neurodegenerative disease

The portfolio reflects a focus on therapies intended to address disease processes within the brain and support measurable neurological outcomes.

About Specializations

Denali Therapeutics Inc. runs clinical trials in conditions such as Mucopolysaccharidosis II, Glycogen storage disease type II, Frontotemporal dementia, Parkinson's disease, among others.

Recruiting now

Ongoing trials

Clinical trials run by this sponsor – those enrolling participants first.

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Type of trial
Recruitment status
Quick filters

6 clinical trials

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of DNL952 in Adults with Late‑Onset Pompe Disease

InvestigationalNo placebo
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Sponsor:Denali Therapeutics Inc.

Study on the Safety and Effects of DNL593 for Patients with Frontotemporal Dementia

Registered drug
Countries:BelgiumBelgium
  • Participants:18–64 years · 65+ years · Healthy volunteers
  • Substances:DNL593
  • Sponsor:Denali Therapeutics Inc.

Study on Long-Term Safety and Effects of DNL310 for Patients with Mucopolysaccharidosis Type II (MPS II)

InvestigationalNo placebo
Countries:BelgiumBelgium
  • Participants:0–17 years · 18–64 years
  • Substances:Iduronate-2-Sulfatase Fused To A Fc Polypeptide That Binds To The Human Transferrin Receptor
  • Sponsor:Denali Therapeutics Inc.

Parkinson's disease

Not recruiting

Study on the Safety and Effects of BIIB122 for Patients with LRRK2-Associated Parkinson's Disease

Investigational
Countries:GermanyGermany
  • Participants:18–64 years · 65+ years
  • Substances:N2-(3-(2-(2H-1,2,3-Triazol-2-Yl)Propan-2-Yl)-1-Cyclopropyl-1H-Pyrazol-5-Yl)-N4-Ethyl-5-(Trifluoromethyl)Pyrimidine-2,4-Diamine
  • Sponsor:Denali Therapeutics Inc.

Study on the Effectiveness and Safety of DNL310 vs Idursulfase for Children and Young Adults with Mucopolysaccharidosis Type II

Registered drugNo placebo
Countries:BelgiumBelgium
  • Participants:0–17 years · 18–64 years
  • Substances:Idursulfase
  • Sponsor:Denali Therapeutics Inc.

Study on the Safety of DNL310 for Children with Hunter Syndrome

InvestigationalNo placebo
Countries:The NetherlandsThe Netherlands
  • Participants:0–17 years · 18–64 years
  • Substances:Iduronate-2-Sulfatase Fused To A Fc Polypeptide That Binds To The Human Transferrin Receptor
  • Sponsor:Denali Therapeutics Inc.

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