Clinical trials in Brest – page 8

591 clinical trials in Brest, France across 1 research site. Every trial is listed in the EU Clinical Trials Register and updated daily.

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591 trials in Brest

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Breast cancer+2

Recruiting

Study of PF-07248144 and fulvestrant in adults with hormone receptor-positive, HER2-negative advanced or metastatic breast cancer who had progression after CDK4/6 inhibitor therapy

Registered drugNo placebo

Study of PF-07248144 and fulvestrant in adults with hormone receptor-positive, HER2-negative advanced or metastatic breast cancer who had progression after CDK4/6 inhibitor therapy

Registered drugNo placebo

France

Participants:18–64 years · 65+ years
Substances:Everolimus
Sponsor:Pfizer Inc.

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Asthma

Recruiting

Study of depemokimab to improve airway function in patients with type 2 eosinophilic asthma

InvestigationalNo placebo

Study of depemokimab to improve airway function in patients with type 2 eosinophilic asthma

InvestigationalNo placebo

France

Participants:18–64 years · 65+ years
Substances:Depemokimab
Sponsor:Glaxosmithkline Research & Development Limited

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Adenocarcinoma pancreas

Recruiting

Study of Gemcitabine with Paclitaxel versus Standard Chemotherapy Combination for Patients with Borderline Resectable Pancreatic Cancer Based on Gene Analysis

Registered drugNo placebo

Study of Gemcitabine with Paclitaxel versus Standard Chemotherapy Combination for Patients with Borderline Resectable Pancreatic Cancer Based on Gene Analysis

Registered drugNo placebo

France

Participants:18–64 years · 65+ years
Substances:Fluorouracil
Sponsor:Fondation Franc.Cancerologie Digestive

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Small cell lung cancer recurrent

Recruiting

Study comparing GSK5764227 and topotecan in adults with relapsed small cell lung cancer

Registered drugNo placebo

Study comparing GSK5764227 and topotecan in adults with relapsed small cell lung cancer

Registered drugNo placebo

France

Participants:18–64 years · 65+ years
Substances:GSK5764227
Sponsor:Glaxosmithkline Research & Development Limited

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Pulmonary arterial hypertension

Recruiting

A study of LTP001 in combination with standard treatment for adults with pulmonary arterial hypertension

Investigational

A study of LTP001 in combination with standard treatment for adults with pulmonary arterial hypertension

Investigational

France

Participants:18–64 years · 65+ years · Healthy volunteers
Substances:LTP001
Sponsor:Novartis Pharma AG

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Pulmonary arterial hypertension

Recruiting

Study comparing tadalafil with ambrisentan versus tadalafil alone in newly diagnosed patients with pulmonary arterial hypertension who have cardiovascular conditions

Registered drug

Study comparing tadalafil with ambrisentan versus tadalafil alone in newly diagnosed patients with pulmonary arterial hypertension who have cardiovascular conditions

Registered drug

France

Participants:18–64 years · 65+ years
Substances:Ambrisentan
Sponsor:Assistance Publique Hopitaux De Paris

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Craniocerebral injury

Recruiting

Study of hypertonic saline solution and mannitol to improve recovery in patients with traumatic brain injury and high risk of intracranial hypertension

Registered drugNo placebo

Study of hypertonic saline solution and mannitol to improve recovery in patients with traumatic brain injury and high risk of intracranial hypertension

Registered drugNo placebo

France

Participants:0–17 years · 18–64 years · 65+ years
Substances:Mannitol
Sponsor:Centre Hospitalier Universitaire De Nantes

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Gastroenteropancreatic neuroendocrine tumour disease+1

Recruiting

Study of Gallium (68Ga) edotreotide, Fluorocholine (18F) and Fludeoxyglucose (18F) PET imaging for detection and staging of liver cancer and gastro-entero-pancreatic tumors

Registered drugNo placebo

Study of Gallium (68Ga) edotreotide, Fluorocholine (18F) and Fludeoxyglucose (18F) PET imaging for detection and staging of liver cancer and gastro-entero-pancreatic tumors

Registered drugNo placebo

France

Participants:18–64 years · 65+ years
Substances:Fludeoxyglucose (18F)
Sponsor:Centre Hospitalier Universitaire De Nantes

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Lung neoplasm malignant

Recruiting

Comparing Lung Perfusion PET/CT-Guided Versus Standard Planning for Stereotactic Body Radiotherapy in Patients with Primary or Secondary Lung Tumors

InvestigationalNo placebo

Comparing Lung Perfusion PET/CT-Guided Versus Standard Planning for Stereotactic Body Radiotherapy in Patients with Primary or Secondary Lung Tumors

InvestigationalNo placebo

France

Participants:18–64 years · 65+ years
Substances:Gallium (68GA)
Sponsor:Centre Hospitalier Regional Et Universitaire De Brest

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Dermatitis atopic

Recruiting

Study of GHZ339 for treatment of moderate to severe atopic dermatitis

Registered drug

Study of GHZ339 for treatment of moderate to severe atopic dermatitis

Registered drug

France

Participants:18–64 years · 65+ years
Substances:GHZ339
Sponsor:Novartis Pharma AG

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Chronic obstructive pulmonary disease

Recruiting

Study of dupilumab injections to reduce airway inflammation in adults aged 40-85 with chronic obstructive pulmonary disease

Registered drug

Study of dupilumab injections to reduce airway inflammation in adults aged 40-85 with chronic obstructive pulmonary disease

Registered drug

France

Participants:18–64 years · 65+ years
Substances:Dupilumab
Sponsor:Sanofi-Aventis Recherche & Developpement

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Gastric cancer stage IV+1

Recruiting

Study of ivonescimab with chemotherapy combination for first and second-line treatment in patients with advanced or metastatic gastric and gastroesophageal cancer

Registered drugNo placebo

Study of ivonescimab with chemotherapy combination for first and second-line treatment in patients with advanced or metastatic gastric and gastroesophageal cancer

Registered drugNo placebo

France

Participants:18–64 years · 65+ years
Substances:Calcium Levofolinate
Sponsor:Unicancer

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Clinical research in Brest

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01 Oncology Research

Groundbreaking trials focusing on head and neck squamous cell carcinoma, exploring innovative treatments combining radiotherapy with targeted therapies. Studies also examine new approaches for esophageal cancer and pancreatic adenocarcinoma.

Advanced Cancer Therapies
Combination Treatments
Targeted Therapeutics

Multiple trials are investigating novel drug combinations and immunotherapy approaches for various cancer types.

02 Autoimmune Conditions

Comprehensive research into Sjögren's syndrome treatment options, including innovative biological therapies and histopathological studies. Additional focus on rheumatoid arthritis and novel therapeutic approaches.

Biological Treatments
Disease Mechanisms
Treatment Response

Studies aim to understand disease mechanisms and evaluate new therapeutic options for autoimmune disorders.

03 Cardiovascular and Respiratory Studies

Investigation of treatments for pulmonary arterial hypertension and heart failure prevention. Research includes innovative drug combinations and preventive approaches for cardiovascular conditions.

Heart Failure Prevention
Hypertension Management
Asthma Control

Focus on developing effective treatments for chronic cardiovascular and respiratory conditions.

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