Post procedural complication Trials in Disease

Evaluation of inhaled formoterol fumarate to prevent lung complications after chest cancer surgery in high-risk patients

This trial is being conducted in France and focuses on preventing breathing problems that can develop after chest surgery for lung cancer. The study examines whether using an inhaled medication called formoterol fumarate can help reduce lung complications in the week following surgery.

Who can participate:

• Adults aged 18 years or older
• Patients diagnosed with non-small-cell lung cancer that can be treated with surgery
• People with reduced lung function, specifically with a breathing test result showing less than 80% of normal capacity
• Those who have never used long-term inhaler medications before
• Patients with active health insurance coverage
• Individuals able to understand and sign an informed consent form

Who cannot participate:

• People younger than 18 years
• Those with a history of severe allergic reactions to bronchodilators
• Patients with uncontrolled asthma or severe breathing problems
• Pregnant or breastfeeding women
• Those who have used bronchodilator medications within 24 hours before surgery
• Emergency surgery cases
• People unable to perform breathing tests or follow study instructions
• Patients with severe heart conditions that could be worsened by bronchodilators
• Those currently participating in other clinical trials
• People with serious liver or kidney problems

What the trial involves:

The study aims to evaluate whether inhaled formoterol fumarate, a medication that helps open airways in the lungs, can prevent breathing complications after chest surgery. Participants will be divided into two groups—one receiving the breathing medication through an inhaler and another not receiving it. Doctors will monitor patients for any breathing problems that develop within 7 days after surgery, as well as track their recovery up to 6 months later. The medical team will also watch for potential side effects such as rapid heartbeat, headaches, or changes in blood sugar levels.

Investigational drug:

The trial uses inhaled bronchodilator therapy delivered through an inhaler device. This medication works by relaxing the muscles around the airways, making breathing easier both before and after surgery.

Study on the Effect of Methylprednisolone Injection for Reducing Swelling, Stiffness, and Pain After Lower Wisdom Tooth Surgery in Patients

This trial is taking place in Hungary and explores whether an injection given before wisdom tooth removal can improve recovery. The study examines the effects of methylprednisolone hemisuccinate on common issues that arise after surgery, including swelling, difficulty opening the mouth, and pain.

Who can participate:

• Adults between 18 and 50 years old
• People with lower wisdom teeth on both sides of the mouth
• Patients whose wisdom teeth are deeply impacted and in similar positions on both sides
• Those in good overall health
• People not taking medications that could interfere with the treatment
• Individuals with good oral hygiene
• Both males and females

Who cannot participate:

• People not experiencing any issues after surgery
• Those outside the 18 to 50 age range
• Individuals considered part of a vulnerable population who might need special protection or care

What the trial involves:

This research investigates whether an injection of methylprednisolone given before wisdom tooth surgery can help patients recover more comfortably. The study is designed as a randomized, double-blind trial, meaning neither participants nor researchers know who receives the actual medication or a placebo. Participants receive an injection into the masseter muscle before their surgery, and researchers then monitor how well they recover, paying particular attention to swelling, difficulty opening the mouth, and pain levels.

Investigational drug:

Methylprednisolone is a corticosteroid medication injected into the masseter muscle before surgery. It works by reducing inflammation and the body's immune response, which can help decrease swelling, pain, and difficulty opening the mouth after wisdom tooth removal.

Summary

These two clinical trials represent different approaches to managing complications after surgical procedures. The French study focuses on respiratory care following major chest surgery for lung cancer patients, while the Hungarian trial addresses recovery after a common dental procedure. Both studies share a common goal of improving patient comfort and reducing post-surgical complications through preventive medication strategies. The trials are geographically diverse, with one study in France and another in Hungary, reflecting international interest in improving surgical recovery outcomes across different medical specialties.