Rare diseases
Investigational molecules
Locations
Back to Czechia95 clinical trials in Brno-Sever, Czechia across 1 research site. Every trial is listed in the EU Clinical Trials Register and updated daily.
Our site in CzechiaKlinickeTesty.cz(opens in a new tab)Study on the Effectiveness and Safety of Bimekizumab and Risankizumab in Adults with Active Psoriatic Arthritis
CzechiaBaricitinib Compared with Adalimumab and Etanercept in Patients with Rheumatoid Arthritis
CzechiaA study to evaluate the efficacy and safety of vixarelimab in patients with moderate to severe ulcerative colitis
CzechiaA study to evaluate the long-term safety and effectiveness of balinatunfib in adults with Crohn's disease or ulcerative colitis
CzechiaEfficacy and Safety Evaluation of Litifilimab in Adults with Active Systemic Lupus Erythematosus on Standard Nonbiologic Lupus Care: A Phase 3 Randomized Controlled Trial
CzechiaLong-term study of dabrafenib and trametinib in children and adolescents with cancers that have V600 mutation
CzechiaStudy of rimegepant for preventing chronic migraine in adolescents aged 12 to 17 years
CzechiaStudy of SAR441566 compared to placebo for adults with moderate to severe Crohn's disease
CzechiaStudy on the Effects of Abiprubart for Patients with Sjögren’s Disease
CzechiaStudy on the Effects of Zasocitinib for Patients with Moderate to Severe Ulcerative Colitis
CzechiaStudy of Palbociclib with Drug Combinations for Children and Young Adults with Recurrent or Refractory Neuroblastoma and Ewing Sarcoma
CzechiaStudy on the Effects of Ianalumab in Adults with Rheumatoid Arthritis, Systemic Lupus Erythematosus, or Sjögren’s Disease
CzechiaThe busiest research cities in the country
What the registry says about research in the country
Clinical trials in Brno-Sever are strongly focused on digestive system diseases, especially Crohn’s disease and ulcerative colitis. These studies are mainly testing new ways to control inflammation, improve symptom relief, and support long-term disease management.
Many of these trials aim to improve remission rates and overall quality of life for people living with chronic bowel inflammation.
A major part of the research landscape covers immune system diseases and musculoskeletal diseases, including rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, and systemic lupus erythematosus. The trials are exploring better ways to reduce pain, stiffness, swelling, and long-term joint damage.
This area is especially active in the city, reflecting a broad effort to advance treatment options for chronic inflammatory conditions.
Trials in respiratory tract diseases and allergic conditions are examining asthma and seasonal allergic rhinitis. The main goal is to assess whether new therapies can better support breathing, reduce flare-ups, and ease allergy-related symptoms in children and adults.
These studies help expand options for people living with common but often disruptive respiratory and allergy problems.
Research in cardiovascular diseases and nutritional and metabolic diseases includes studies in high cardiovascular risk, atherosclerotic cardiovascular disease, hypertension, and obesity. The trials are designed to improve prevention and lower the risk of serious heart-related events.
Several studies also look at how better lipid control and weight-related care may support long-term heart health.
A broad oncology portfolio is active across neoplasms, with studies in acute myeloid leukemia, acute lymphoblastic leukemia, neuroblastoma, medulloblastoma, and other solid tumors. These trials are focused on improving outcomes for children, adolescents, and young adults with difficult-to-treat cancers.
In Brno-Sever, cancer research spans both common hematologic malignancies and rarer childhood tumors.
Clinical trials also cover skin and connective tissue diseases such as atopic dermatitis, psoriatic disease, and Netherton syndrome. The research is aimed at reducing inflammation, relieving itch and skin irritation, and improving daily comfort for patients.
These studies reflect a strong interest in targeted treatments for chronic and often visible skin conditions.
Trials in nervous system diseases include work on chronic migraine and muscular dystrophy, along with other conditions affecting movement and quality of life. The focus is on prevention, symptom reduction, and longer-term support for patients and families.
These trials aim to address both frequent symptoms and the broader burden of chronic neurological disease.
Several studies focus on congenital, hereditary, and neonatal diseases, including achondroplasia, osteochondrodysplasia, and childhood-onset inflammatory disorders. This area also includes research in children with complex immune, metabolic, and developmental conditions.
These trials are important for building evidence where treatment choices are often limited.
Research in hemic and lymphatic diseases includes hemophilia A and B, anemia associated with chronic kidney disease, and neutropenias. The studies are designed to improve blood-related outcomes, reduce complications, and support more stable disease control.
This area supports both inherited bleeding disorders and acquired blood count problems.
Although smaller in volume, trials in eye diseases and stomatognathic diseases contribute to a wider research portfolio. These studies may address vision-related concerns as well as conditions affecting the mouth and surrounding structures.
They add further breadth to the clinical trial activity seen across the city.
Some trials span several therapeutic areas and focus on rare or complex disorders such as juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis, polymyalgia rheumatica, and myocardial and metabolic overlap conditions. These studies often aim to refine treatment choices where disease patterns are diverse and hard to manage.
This research adds an important rare-disease dimension to the trial landscape in Brno-Sever.
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