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Clinical trials in Brno-Zidenice – page 3

73 clinical trials in Brno-Zidenice, Czechia across 1 research site. Every trial is listed in the EU Clinical Trials Register and updated daily.

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Brno-Zidenice at a glance
73
clinical trials
  • Paediatric trials0
  • Research sites1
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73 trials in Brno-Zidenice

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Crohn's disease

Recruiting

Study on the Effects of Zasocitinib for Patients with Moderate to Severe Crohn's Disease

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Zasocitinib
  • Sponsor:Takeda Development Center Americas Inc.

Study on Long-Term Safety of Secukinumab for Patients with Psoriatic Arthritis, Ankylosing Spondylitis, and Severe Chronic Plaque Psoriasis

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:0–17 years · 18–64 years · 65+ years
  • Substances:Secukinumab
  • Sponsor:Novartis Pharma AG

Atrial fibrillation

Not yet recruiting

Prevention of Stroke and Systemic Embolism in Atrial Fibrillation Patients Treated with REGN7508 (cenvacibart) versus Apixaban

Registered drug
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Apixaban
  • Sponsor:Regeneron Pharmaceuticals Inc.

Aortic valve stenosis

Not yet recruiting

A Phase 2b/3 Randomized Double‑Blind Study of Ataciguat to Slow Disease Progression in Adults with Moderate Calcific Aortic Valve Stenosis

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Sponsor:Kardigan Inc.

Arteriosclerosis

Not yet recruiting

Study of olpasiran to prevent first major cardiovascular events in people with high levels of lipoprotein(a)

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Sponsor:Amgen Inc.

Crohn's disease

Not yet recruiting

Efficacy and safety of ontunisertib in patients with fibrostenosing Crohn’s disease: a phase 2b randomized, double‑blind, placebo‑controlled dose‑ranging trial

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:ORG-129
  • Sponsor:Agomab Spain S.L.U.

Study of linaprazan glurate and lansoprazole to maintain healing in patients with erosive esophagitis caused by acid reflux disease

Registered drug
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Lansoprazole
  • Sponsor:Cinclus Pharma Holding AB (publ)

Comparison of linaprazan glurate versus lansoprazole for healing of erosive esophagitis in adults with gastroesophageal reflux disease

Registered drug
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Lansoprazole
  • Sponsor:Cinclus Pharma Holding AB (publ)

Arteriosclerosis

Not recruiting

Study of maridebart cafraglutide to reduce cardiovascular problems in overweight or obese patients with atherosclerotic cardiovascular disease

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Maridebart Cafraglutide
  • Sponsor:Amgen Inc.

Cardiac failure

Not recruiting

Evaluation of Ziltivekimab in Patients with Heart Failure with Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Ziltivekimab
  • Sponsor:Novo Nordisk A/S

Psoriatic arthropathy

Not recruiting

Study on the Effectiveness and Safety of JNJ-77242113 for Patients with Active Psoriatic Arthritis Who Have Not Used Biologic Treatments

Registered drug
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:JNJ-77242113
  • Sponsor:Janssen Cilag International

Osteoarthritis

Not recruiting

Study on the Effects of LNA043 for Patients with Knee Osteoarthritis

InvestigationalNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:LNA043
  • Sponsor:Novartis Pharma AG

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Clinical research in Brno-Zidenice

What the registry says about research in the country

01 Cardiovascular Diseases

In Brno-Zidenice, cardiovascular research is strongly represented, with studies focused on heart failure, atrial fibrillation, acute coronary syndromes, hypertension, and broader atherosclerotic cardiovascular disease. These trials are designed to test new treatment options, reduce major cardiovascular events, and improve long-term heart and circulation outcomes.

  • Heart failure, including reduced and preserved ejection fraction
  • Atrial fibrillation and stroke prevention
  • High cardiovascular risk and prevention of major cardiac events
  • Evaluating new therapies for better control of symptoms and event reduction

Much of this work aims to improve protection against hospitalization, stroke, and cardiovascular death, while also supporting safer, more effective care for people living with chronic heart conditions.

02 Digestive System Diseases

Clinical trials in digestive system diseases are especially active, covering Crohn’s disease, ulcerative colitis, coeliac disease, and gastroesophageal reflux disease. Researchers are primarily looking at whether new treatments can better control inflammation, promote remission, and improve everyday digestive symptoms.

  • Crohn’s disease and ulcerative colitis
  • Coeliac disease and intestinal inflammation
  • Erosive esophagitis linked to GERD
  • Testing therapies aimed at remission, healing, and symptom relief

This area reflects a broad effort to advance both induction and maintenance treatments for inflammatory bowel conditions, as well as better options for upper digestive tract disease.

03 Immune System Diseases

Immune-focused studies in this city explore conditions such as psoriatic arthritis, rheumatoid arthritis, axial spondyloarthritis, giant cell arteritis, and polymyalgia rheumatica. The main goal is to understand how new immune-targeted therapies can reduce inflammation, improve mobility, and ease persistent disease symptoms.

  • Psoriatic arthritis and axial spondyloarthritis
  • Rheumatoid arthritis and related inflammatory joint disease
  • Giant cell arteritis and polymyalgia rheumatica
  • Assessing immune-modulating treatments for symptom control

These trials support the search for more precise therapies that can calm immune-driven inflammation while helping patients maintain function and quality of life.

04 Musculoskeletal Diseases

Research in musculoskeletal diseases overlaps with inflammatory joint disorders and includes studies in osteoarthritis, juvenile idiopathic arthritis, and related spine and joint conditions. The focus is on easing pain, improving joint function, and finding treatments that can slow disease impact over time.

  • Osteoarthritis of the knee and other joints
  • Juvenile idiopathic arthritis
  • Inflammatory spine and joint disorders
  • Evaluating treatments that may reduce pain and improve movement

These studies aim to broaden options for patients whose daily activities are affected by chronic joint inflammation or degenerative joint damage.

05 Nutritional and Metabolic Diseases

Trials in nutritional and metabolic diseases address obesity, overweight, type 2 diabetes, and complications linked to cardiometabolic risk. They are designed to explore whether new approaches can improve weight-related health, lower cardiovascular risk, and support better metabolic control.

  • Obesity and overweight
  • Type 2 diabetes
  • Lipoprotein(a) and other risk-related metabolic factors
  • Testing therapies aimed at weight and cardiometabolic improvement

These studies often connect metabolic health with heart protection, reflecting the close relationship between weight, blood sugar, and cardiovascular disease.

06 Skin and Connective Tissue Diseases

In the field of skin and connective tissue diseases, trials are centered on psoriasis and inflammatory conditions that affect both skin and joints. Researchers are evaluating new therapies that may better control visible symptoms while also addressing deeper immune activity.

  • Severe chronic plaque psoriasis
  • Psoriatic arthritis with skin and joint involvement
  • Inflammatory conditions affecting skin and connective tissue
  • Assessing treatments for symptom reduction and disease control

These studies highlight the need for therapies that can manage both the physical burden and the long-term inflammatory nature of these conditions.

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