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Clinical trials in Prague – page 20

1 231 clinical trials in Prague, Czechia across 17 research sites. Every trial is listed in the EU Clinical Trials Register and updated daily.

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Prague at a glance
1 231
clinical trials
  • Research sites17
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1 231 trials in Prague

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Study of BMS-986368 to treat muscle stiffness in people with Multiple Sclerosis

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:CC-97489
  • Sponsor:Celgene Corp.

Study of sonrotoclax plus obinutuzumab or rituximab compared to venetoclax plus rituximab in patients with relapsed or refractory chronic lymphocytic leukemia

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Obinutuzumab
  • Sponsor:BeOne Medicines AG

Ovarian cancer

Recruiting

Study of trastuzumab deruxtecan with bevacizumab versus bevacizumab alone as first-line maintenance treatment for patients with HER2-expressing ovarian cancer

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Bevacizumab
  • Sponsor:Daiichi Sankyo Inc.

Study of VHB937 to evaluate its effects on cognition and function in people with early Alzheimer's Disease over 72 weeks

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:VHB937
  • Sponsor:Novartis Pharma AG

Study of Port Delivery System with ranibizumab given every 36 weeks in patients with neovascular age-related macular degeneration

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Ranibizumab
  • Sponsor:F. Hoffmann-La Roche AG

Study of datopotamab deruxtecan with platinum-based therapy compared to gemcitabine with platinum-based therapy in patients with advanced urothelial cancer after prior treatment

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Carboplatin
  • Sponsor:Daiichi Sankyo Inc.

Evaluating sacituzumab tirumotecan alone or with pembrolizumab compared to standard treatment in untreated patients with metastatic triple-negative breast cancer with low PD-L1 expression

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Carboplatin
  • Sponsor:Merck Sharp & Dohme LLC

Long-term safety and effectiveness study of CYB003 (deupsilocin besilate) with optional additional doses for people with Major Depressive Disorder

InvestigationalNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Deupsilocin besilate
  • Sponsor:Cybin IRL Limited

Study of Bleximenib, Venetoclax, and Azacitidine Treatment for Newly Diagnosed Acute Myeloid Leukemia Patients Ineligible for Intensive Chemotherapy

Registered drug
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Azacitidine
  • Sponsor:Janssen Cilag International

Cardiac failure

Recruiting

Evaluating the Effect of Vicadrostat and Empagliflozin Combination Compared to Empagliflozin Alone in Patients with Heart Failure and Reduced Left Ventricular Function

Registered drug
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:BI 690517
  • Sponsor:Boehringer Ingelheim International GmbH

Hepatitis D

Recruiting

Clinical Trial for Patients with Chronic Hepatitis D: Comparing Brelovitug and Bulevirtide Treatments

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:BJT-778
  • Sponsor:Mirum Pharmaceuticals Inc.

Study on the Safety and Effectiveness of Telisotuzumab Adizutecan and Drug Combination for Patients with Metastatic Colorectal Cancer

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Bevacizumab
  • Sponsor:AbbVie Deutschland GmbH & Co. KG

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Clinical research in Prague

What the registry says about research in the country

01 Neoplasms and Oncology

Clinical trial activity in Praha includes research in advanced melanoma and diffuse large B-cell lymphoma, with a strong focus on improving cancer control and extending survival.

  • Advanced melanoma
  • Previously untreated diffuse large B-cell lymphoma
  • Testing new treatment combinations
  • Evaluating survival outcomes and disease progression

These studies are designed to refine how immunotherapy and other cancer treatments perform in everyday clinical care.

02 Cardiovascular Diseases

Research in cardiovascular diseases is centered on reducing major heart and vascular events, with trials looking at hypertension, atherosclerotic cardiovascular disease, and heart failure prevention.

  • Hypertension
  • Atherosclerotic cardiovascular disease
  • Prevention of heart failure
  • Lowering the risk of stroke and other vascular complications

Several studies aim to improve treatment effectiveness for patients at elevated cardiovascular risk.

03 Respiratory Tract Diseases

Trials in the respiratory field focus on better symptom control and fewer flare-ups in chronic obstructive pulmonary disease, alongside ongoing work in infection-related lung illness.

  • Chronic obstructive pulmonary disease
  • Covid-19 in people at high risk of severe illness
  • Testing new antiviral and anti-inflammatory approaches
  • Reducing exacerbations and severe outcomes

These studies support more effective care for both chronic and acute respiratory conditions.

04 Skin and Connective Tissue Diseases

Dermatology research in Czechia includes several inflammatory skin disorders, with studies targeting itch, lesion control, and long-term disease management.

  • Atopic dermatitis
  • Moderate to severe plaque psoriasis
  • Hidradenitis suppurativa
  • Neurodermatitis and lichen simplex chronicus

The goal is to evaluate new therapies that may ease symptoms and improve quality of life.

05 Immune System Diseases

Studies in immune-mediated disease are exploring treatments that can calm abnormal inflammation while maintaining safety and tolerability.

  • Psoriatic arthritis
  • Atopic dermatitis
  • Psoriasis-related inflammatory conditions
  • Assessing immune-targeted therapy effectiveness

These trials aim to improve control of chronic immune-driven disease burden.

06 Nervous System Diseases

Neurology-related research focuses on agitation in Alzheimer's disease dementia, with efforts to better manage behavioral symptoms that affect patients and caregivers.

  • Agitation in Alzheimer's disease dementia
  • Symptom relief and behavioral improvement
  • Evaluating new therapeutic options

These studies may help support more practical care for people living with dementia.

07 Nutritional and Metabolic Diseases

Metabolic research in Praha includes trials for overweight, obesity, and related conditions, often linked with cardiovascular risk.

  • Overweight and obesity
  • Hypertension with obesity
  • Type 2 diabetes-related weight management
  • Supporting weight loss and cardiometabolic health

These studies are testing approaches that may help reduce long-term health risks tied to excess weight.

08 Virus Diseases

In the area of virus diseases, research is centered on improving treatment options for people with COVID-19 who are at higher risk of becoming seriously ill.

  • COVID-19 at high risk of progression
  • Reducing illness severity
  • Testing antiviral treatment effectiveness

The main aim is to help prevent worsening disease and support faster recovery.

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